The College Board recognized 27 Islip High School students as Advanced Placement Scholars for exceptional achievement on the May 2021 national exams. Additionally, 16 students qualified to receive an AP Seminar and Research Certificate, and six students qualified to receive an AP Capstone diploma upon graduation in June 2022. AP courses completed with a score of 3 or higher on the final exam may afford students the opportunity to earn college credit.

- Ten students qualified for the AP Scholar Award by receiving a 3 or higher on three or more exams and include: Jesse Caro, Sean Files, Keera Kittles, Juliana Marconi, Angela Padilla, Hasnayn Raza, James Wimmers, Cassandra Zaneski, Brianna Zavala, Abby Zimmermann.

- Eight students received the AP Scholar with Honor Award by earning an average grade of 3.25 on all AP exams taken and grades of 3 or higher on four or more exams and include: Sarah Alvarez, Selina Chan, Bipro Dhar, Connor Edwards, Hannah Evans, Madeline Mulholland, Desiree Pagan and Yousuf Shrivardhankar

- Nine students were recognized as AP Scholars with Distinction by earning an average of at least a 3.5 on all AP exams taken and grades of three or higher on five or more exams and include: Liam Biscari, Carolyn Do, Joyce Johnson, Carlo Lanza, Anthony Lopez, Timothy Mak, Justin Rhodes, Richard Rindos, Steven Schadt

- Sarah Alvarez, Richie Castronova, Selina Chan, Carolyn Do, Connor Edwards, Sean Files, Kayla Hassell, Joyce Johnson, Ava Kurka, Carlo Lanza, Angela Padilla, Hasnayn Raza, Justin Rhodes, Richard Rindos, Steven Schadt and Serena Trabacchi have qualified to receive an AP Seminar and Research Certificate upon graduation.

- Liam Biscari, Bipro Dhar, Keera Kittles, Anthony Lopez, Timothy Mak and Desiree Pagan will receive an AP Capstone Diploma upon graduation.